The TRC, in preliminary findings communicated to the parties last month, said it would hold the ANC, the PAC and their armed wings "morally and politically accountable" for the commission of gross human rights violations between 1960 and 1994.
The final report will be handed over to President Nelson Mandela on Thursday, after parties were given the opportunity to make written submissions in reply to the preliminary findings.
In section 30 notices to the ANC and the PAC - leaked to the media on Monday - the TRC endorsed the international position that apartheid was a crime against humanity.
It acknowledged that both organisation's were liberation movements, conducting a legitimate struggle against the former apartheid state.
In its three-page preliminary findings against the PAC, the TRC said it had found a deliberate strategy on the part of the Azanian People's Liberation Army (Apla) to attack civilian targets.
In a sub section titled "attacks on white farmers", the commission said the PAC's strategy in 1993 to drive farmers off the land so that it could be reclaimed by African people had resulted in the deaths of a number of civilians.
"The commission finds that these killings constitute gross violations of human rights, in spite of the PAC's explanation of them as acts of war, for which - according to the director of operations - no regrets and apologies are due by them."
The TRC also blamed the PAC for gross human rights violations committed against its own members.
"The commission finds that during the internal conflict within the organisation... killings and assassinations were carried out on members belonging to different factions within the movement".
It also found the PAC was responsible for killing members within the country who were opposed to their policies, as well as those identified as informers and spies.
The TRC did not name individual PAC members.
However, in its notice to the ANC, its said the party must accept responsibility for the activities of ANC Women's League president Winnie Madikizela-Mandela and her Mandela United Football Club.
The TRC said although it was ANC policy that the loss of civilian life should be avoided, a number of bomb attacks had taken place where there was a "blurring" between military and civilian targets.
These included the planting of landmines in the Northern and Eastern Transvaal.
The ANC's military tribunal decision to execute enemy agents was also a gross human rights violation. In many instances, suspects were brought before the tribunal without proper attention to due process.
The TRC also detailed various forms of torture used by the ANC, and the severe ill-treatment of a number of ANC cadres in its camps in exile.
The commission found that many people died because of punitive starvation or assault between 1979 and 1989.
The commission also found that the ANC was responsible for the killing of political opponents, including members of the Inkatha Freedom Party and the PAC, between 1990 and 1994.