The commission in a statement on Friday said many anti-apartheid and anti-Bophuthatswana government activities were carried out from the university.
The commission hoped to hear testimony from about 30 witnesses during its three-days sitting in Mmabatho.
Testimony would be heard from people from Vryheid, Zeerust amd Mmabatho.
People who had not yet made submissions to the commission were invited to do so, the statement said.
Truth commissioners Dr Fazel Randera, Prof Piet Meiring and Ms Joyce Seroke will preside over the hearings.