The hearing at the Nico Malan Nursing College in Heideveld, Cape Town, followed last week's hearings in East London.
On Thursday the commission faces a Cape Town Supreme Court challenge from the families of three slain anti-apartheid activists.
Their application to suspend the operation of the commission's amnesty committee, which started considering applications for amnesty for apartheid-era political offences on Wednesday, was postponed to Thursday.
Cyril Morolo, attorney for the families of black-consciousness leader Steve Biko, anti-apartheid lawyer Griffiths Mxenge and African National Congress activist Dr Fabian Ribeiro, objected to the committee considering amnesty applications.
He said the the families' Constitutional Court application challenging amnesty provisions in legislation governing the commission would be prejudiced if the hearings went ahead.
The state was obliged, in terms of international law, to "criminalise, prosecute and punish war crimes and crimes against humanity,"he said.
However, the application was postponed to Thursday when the amnesty committee, chaired by Justice Hassen Mall, continues its meeting.
The committee was deciding whether the 60 applications met the requirements of the Promotion of National Unity and Reconciliation Act.
It was possible that "decisons to grant or reject applications could be made this week," it said.
Such decisions would not be disclosed by the committee, but would be forwarded to the full commission.
In terms of the legislation governing the commission, the committee may grant amnesty to people guilty of political offences who make a full disclosure of their abuses.
The committee said announcements on amnesty hearings would be made "in due course".